Release date: 26 June 2024 (Last updated: 28 June 2024)

TetraScience has released its next version of the Tetra Data Platform (TDP), version 4.0.3. This release includes several enhancements to help ensure data integrity. It also introduces the Tetra Skyline Data App (beta release), which provides scientists the ability to access Tetra Data on their local desktop directly through Skyline, a platform for analyzing mass spectrometer data.

Here are the details for what’s new in TDP v4.0.3.

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Security

TetraScience continually monitors and tests the TDP codebase to identify potential security issues. Various security updates are applied to the following areas on an ongoing basis:

• Operating systems
• Third-party libraries

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Quality Management

TetraScience is committed to creating quality software. Software is developed and tested following the ISO 9001-certified TetraScience Quality Management System. This system ensures the quality and reliability of TetraScience software while maintaining data integrity and confidentiality.

New Functionality

New functionalities are features that weren’t previously available in the TDP.

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GxP Impact Assessment

All new TDP functionalities go through a GxP impact assessment to determine validation needs for GxP installations. New Functionality items marked with an asterisk (*) address usability, supportability, or infrastructure issues, and do not affect Intended Use for validation purposes, per this assessment. Enhancements and Bug Fixes do not generally affect Intended Use for validation purposes, and items marked as beta release are not suitable for GxP use.

Data Access and Management New Functionality

Tetra Skyline Data App (Beta Release)*

The Tetra Skyline Data App provides scientists the ability to access Tetra Data on their local desktop directly through Skyline, a platform for analyzing mass spectrometer data. By using this new Embedded Data App based on Windows, scientists can now build selected reaction monitoring (SRM) and multiple reaction monitoring (MRM), parallel reaction monitoring (PRM), data independent acquisition (DIA/SWATH) and DDA with MS1 quantitative methods, and then analyze the resulting data without leaving the TDP user interface.

The Tetra Skyline Data App is in beta release currently and may require changes in future TDP releases. If you are interested in using it, please contact your customer success manager (CSM).

For more information, see Embedded Data Apps.

Enhancements

Enhancements are modifications to existing functionality that improve performance or usability, but don't alter the function or intended use of the system.

Data Access and Management Enhancements

SQL Tables Now Verify All New IDS Partitions

SQL tables in the TDP now automatically verify the creation of all new Intermediate Data Schema (IDS) table sections (partitions). If a partition check fails, any missing partitions are loaded to the target SQL table. Any partition retry errors are logged in the Health Monitoring dashboard.

The new check prevents SQL tables from being created with missing partitions if an Amazon Athena task fails, or if other infrastructure issues occur. It also allows for file reprocessing jobs to reload partitions to SQL tables if any are missing.

For more information, see TDP Athena SQL Table Structure.

Improved Data Integrity Checks

To help ensure data integrity, a base64-encoded checksum value is now calculated and verified for every RAW file uploaded to the TDP through Tetra Integrations. This action helps validate that each file’s content on the platform matches the local source file’s content.

Bug Fixes

There are no bug fixes in this release.

Deprecated Features

There are no new deprecated features in this release.

For more information about TDP deprecations, see Tetra Product Deprecation Notices.

Known and Possible Issues

The following are known and possible issues for TDP v4.0.3.

Data Harmonization and Engineering Known Issues

• File statuses on the File Processing page can sometimes display differently than the statuses shown for the same files on the Pipelines page in the Bulk Processing Job Details dialog. For example, a file with an Awaiting Processing status in the Bulk Processing Job Details dialog can also show a Processing status on the File Processing page. This discrepancy occurs because each file can have different statuses for different backend services, which can then be surfaced in the TDP at different levels of granularity. A fix for this issue is in development and testing.
• Logs don’t appear for pipeline workflows that are configured with retry settings until the workflows complete.
• Files with more than 20 associated documents (high-lineage files) do not have their lineage indexed by default. To identify and re-lineage-index any high-lineage files, customers must contact their CSM to run a separate reconciliation job that overrides the default lineage indexing limit.
• OpenSearch index mapping conflicts can occur when a client or private namespace creates a backwards-incompatible data type change. For example: If doc.myField is a string in the common IDS and an object in the non-common IDS, then it will cause an index mapping conflict, because the common and non-common namespace documents are sharing an index. When these mapping conflicts occur, the files aren’t searchable through the TDP UI or API endpoints. As a workaround, customers can either create distinct, non-overlapping version numbers for their non-common IDSs or update the names of those IDSs.
• File reprocessing jobs can sometimes show fewer scanned items than expected when either a health check or out-of-memory (OOM) error occurs, but not indicate any errors in the UI. These errors are still logged in Amazon CloudWatch Logs. A fix for this issue is in development and testing.
• File reprocessing jobs can sometimes incorrectly show that a job finished with failures when the job actually retried those failures and then successfully reprocessed them. A fix for this issue is in development and testing.
• On the Pipeline Manager page, pipeline trigger conditions that customers set with a text option must match all of the characters that are entered in the text field. This includes trailing spaces, if there are any.
• File edit and update operations are not supported on metadata and label names (keys) that include special characters. Metadata, tag, and label values can include special characters, but it’s recommended that customers use the approved special characters only. For more information, see Attributes.
• The File Details page sometimes displays an Unknown status for workflows that are either in a Pending or Running status. Output files that are generated by intermediate files within a task script sometimes show an Unknown status, too.

Data Access and Management Known Issues

• Embedded Data Apps based on Windows may not load if a customer’s local web browser’s tracking prevention settings are activated. A fix for this issue is in development and testing, and it currently affects the Tetra FlowJo Data App and Tetra Skyline Data App only. As a workaround, customers can deactivate their browser’s tracking prevention settings. For more information, see An Embedded Data App Based on Windows Won’t Open.
• Text within the context of a RAW file that contains escape (\) or other special characters may not always index completely in OpenSearch. A fix for this issue is in development and testing, and is scheduled for an upcoming release.
• If a data access rule is configured as [label] exists > OR > [same label] does not exist, then no file with the defined label is accessible to the Access Group. A fix for this issue is in development and testing and scheduled for a future TDP release.
• When using SAVED SEARCHES created with the Search Files page (Search (Classic)) prior to TDP v4.0.0, the new Search page can sometimes appear blank. A fix for this issue is in development and testing and planned for a future TDP release. As a workaround, customers should recreate the saved search by using the new Search page.
• File events aren’t created for temporary (TMP) files, so they’re not searchable. This behavior can also result in an Unknown state for Workflow and Pipeline views on the File Details page.
• File events aren’t created for temporary (TMP) files, so they’re not searchable. This behavior can also result in an Unknown state for Workflow and Pipeline views on the File Details page.
• When customers search for labels that include @ symbols in the TDP UI’s search bar, not all results are always returned.
• When customers search for some unicode character combinations in the TDP UI’s Search bar, not all results are always returned.
• If customers modify an existing collection of search queries by adding a new filter condition from one of the Options modals (Basic, Attributes, Data (IDS) Filters, or RAW EQL), but they don't select the Apply button, the previous, existing query is deleted. To modify the filters for an existing collection, customers must select the Apply button in the Options modal before you update the collection. For more information, see How to Save Collections and Shortcuts.
• The File Details page displays a 404 error if a file version doesn't comply with the configured Data Access Rules for the user.

TDP System Administration Known Issues

• The latest Connector versions incorrectly log the following errors in Amazon CloudWatch Logs:
  • Error loading organization certificates. Initialization will continue, but untrusted SSL connections will fail.
  • Client is not initialized - certificate array will be empty
    These organization certificate errors have no impact and shouldn’t be logged as errors. A fix for this issue is currently in development and testing, and is scheduled for an upcoming release. There is no workaround to prevent Connectors from producing these log messages. To filter out these errors when viewing logs, customers can apply the following CloudWatch Logs Insights query filters when querying log groups. (Issue #2818)
    CloudWatch Logs Insights Query Example for Filtering Organization Certificate Errors

  fields @timestamp, @message, @logStream, @log
  | filter message != 'Error loading organization certificates. Initialization will continue, but untrusted SSL connections will fail.'
  | filter message != 'Client is not initialized - certificate array will be empty'
  | sort @timestamp desc
  | limit 20
  

• If a reconciliation job, bulk edit of labels job, or bulk pipeline processing job is canceled, then the job’s ToDo, Failed, and Completed counts can sometimes display incorrectly.

Upgrade Considerations

During the upgrade, there might be a brief downtime when users won't be able to access the TDP user interface and APIs.

After the upgrade, the TetraScience team verifies that the platform infrastructure is working as expected through a combination of manual and automated tests. If any failures are detected, the issues are immediately addressed, or the release can be rolled back. Customers can also verify that TDP search functionality continues to return expected results, and that their workflows continue to run as expected.

For more information about the release schedule, including the GxP release schedule and timelines, see the Product Release Schedule.

For more details about the timing of the upgrade, customers should contact their CSM.

Other Release Notes

To view other TDP release notes, see Tetra Data Platform Release Notes.