Release date: 3 September 2025

TetraScience has released its next version of the Tetra Data Platform (TDP), version 4.3.3. This release includes security enhancements for the platform’s web server configuration and introduces a new UI option to support creating Tetra OpenLab Agents.

Here are the details for what’s new in TDP v4.3.3.

New Functionality

New functionalities are features that weren’t previously available in the TDP.

• There's no new functionality in this release.

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GxP Impact Assessment

All new TDP functionalities go through a GxP impact assessment to determine validation needs for GxP installations.

New Functionality items marked with an asterisk (*) address usability, supportability, or infrastructure issues, and do not affect Intended Use for validation purposes, per this assessment.

Enhancements and Bug Fixes do not generally affect Intended Use for validation purposes.

Items marked as either beta release or early adopter program (EAP) are not validated for GxP by TetraScience. However, customers can use these prerelease features and components in production if they perform their own validation.

Enhancements

Enhancements are modifications to existing functionality that improve performance or usability, but don't alter the function or intended use of the system.

Data Integration Enhancements

New Tetra OpenLab Agent Option and Source Type

With the upcoming release of the Tetra OpenLab Agent planned for early September 2025, customers will be able to ingest Agilent OpenLab data into the Tetra Scientific Data and AI Cloud. For customers planning to use the Tetra OpenLab Agent before TDP v4.4.0 is released, TDP v4.3.3 introduces the required infrastructure to support creating Tetra OpenLab Agents in the TDP UI. To create an Agent, customers will be able to select OpenLab Agent from the Create Agent dialog.

For more information, see Create a New Agent.

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NOTE

Customers can’t create Agents using the OpenLab Agent option until the Tetra OpenLab Agent is generally available.

Infrastructure Updates

There are no infrastructure updates in this release.

Security Updates

Security enhancements have been applied to the platform’s web server configuration.

For more information about specific security updates, contact your customer account leader.

Bug Fixes

There are no bug fixes in this release.

Deprecated Features

There are no new deprecated features in this release.

For more information about TDP deprecations, see Tetra Product Deprecation Notices.

Known and Possible Issues

The following are known and possible issues for the TDP v4.3.3 release.

Data Integrations Known Issues

• When configuring Tetra File-Log Agent paths in the TDP user interface, there are three known issues:

  • Default labels are duplicated in the Agent Details page’s path configuration dropdown after a file with that label is uploaded to the TDP.
  • The End Date field can’t be the same value as the Start Date field. The UI indicates that the End Date can be “on or after the Start Date”.
  • Path configuration options incorrectly appear to be enabled for Agents that have their queues disabled. Any configuration changes made through the TDP UI to an Agent that has its queue disabled won't be applied to the Agent.

  A fix for these issues is in development and testing and is scheduled for a future release.

• For new Tetra Agents set up through a Tetra Data Hub and a Generic Data Connector (GDC), Agent command queues aren’t enabled by default. However, the TDP UI still displays the command queue as enabled when it’s deactivated. As a workaround, customers can manually sync the Tetra Data Hub with the TDP. A fix for this issue is in development and testing and is scheduled for a future release.

Data Harmonization and Engineering Known Issues

• For customers using proxy servers to access the TDP, Tetraflow pipelines created in TDP v4.3.0 and earlier fail and return a CalledProcessError error. As a workaround, customers should disable any existing Tetraflow pipelines and then enable them again. A fix for this issue is in development and testing and is scheduled for a future release.
• The legacy ts-sdk put command to publish artifacts for Self-service pipelines (SSPs) returns a successful (0) status code, even if the command fails. As a workaround, customers should switch to using the latest TetraScience Command Line Interface (CLI) and run the ts-cli publish command to publish artifacts instead. A fix for this issue is in development and testing and is scheduled for a future ts-sdk release.
• IDS files larger than 2 GB are not indexed for search.
• The Chromeleon IDS (thermofisher_chromeleon) v6 Lakehouse tables aren't accessible through Snowflake Data Sharing. There are more subcolumns in the table’s method column than Snowflake allows, so Snowflake doesn’t index the table. A fix for this issue is in development and testing and is scheduled for a future release.
• Empty values in Amazon Athena SQL tables display as NULL values in Lakehouse tables.
• File statuses on the File Processing page can sometimes display differently than the statuses shown for the same files on the Pipelines page in the Bulk Processing Job Details dialog. For example, a file with an Awaiting Processing status in the Bulk Processing Job Details dialog can also show a Processing status on the File Processing page. This discrepancy occurs because each file can have different statuses for different backend services, which can then be surfaced in the TDP at different levels of granularity. A fix for this issue is in development and testing.
• Logs don’t appear for pipeline workflows that are configured with retry settings until the workflows complete.
• Files with more than 20 associated documents (high-lineage files) do not have their lineage indexed by default. To identify and re-lineage-index any high-lineage files, customers must contact their CSM to run a separate reconciliation job that overrides the default lineage indexing limit.
• OpenSearch index mapping conflicts can occur when a client or private namespace creates a backwards-incompatible data type change. For example: If doc.myField is a string in the common IDS and an object in the non-common IDS, then it will cause an index mapping conflict, because the common and non-common namespace documents are sharing an index. When these mapping conflicts occur, the files aren’t searchable through the TDP UI or API endpoints. As a workaround, customers can either create distinct, non-overlapping version numbers for their non-common IDSs or update the names of those IDSs.
• File reprocessing jobs can sometimes show fewer scanned items than expected when either a health check or out-of-memory (OOM) error occurs, but not indicate any errors in the UI. These errors are still logged in Amazon CloudWatch Logs. A fix for this issue is in development and testing.
• File reprocessing jobs can sometimes incorrectly show that a job finished with failures when the job actually retried those failures and then successfully reprocessed them. A fix for this issue is in development and testing.
• File edit and update operations are not supported on metadata and label names (keys) that include special characters. Metadata, tag, and label values can include special characters, but it’s recommended that customers use the approved special characters only. For more information, see Attributes.
• The File Details page sometimes displays an Unknown status for workflows that are either in a Pending or Running status. Output files that are generated by intermediate files within a task script sometimes show an Unknown status, too.
• Some historical protocols and IDSs are not compatible with the new ids-to-lakehouse data ingestion mechanism. The following protocols and IDSs are known to be incompatible with ids-to-lakehouse pipelines:
  • Protocol: fcs-raw-to-ids < v1.5.1 (IDS: flow-cytometer < v4.0.0)
  • Protocol: thermofisher-quantstudio-raw-to-ids < v5.0.0 (IDS: pcr-thermofisher-quantstudio < v5.0.0)
  • Protocol: biotek-gen5-raw-to-ids v1.2.0 (IDS: plate-reader-biotek-gen5 v1.0.1)
  • Protocol: nanotemper-monolith-raw-to-ids v1.1.0 (IDS: mst-nanotemper-monolith v1.0.0)
  • Protocol: ta-instruments-vti-raw-to-ids v2.0.0 (IDS: vapor-sorption-analyzer-tainstruments-vti-sa v2.0.0)

Data Access and Management Known Issues

• Data Apps won’t launch in customer-hosted environments if the private subnets where the TDP is deployed are restricted and don’t have outbound access to the internet. As a workaround, customers should enable the following AWS Interface VPC endpoint in the VPC that the TDP uses: com.amazonaws.<AWS REGION>.elasticfilesystem

  A fix for this issue is in development and testing and is scheduled for a future release.

• Data Apps return CORS errors in all customer-hosted deployments. As a workaround, customers should create an AWS Systems Manager (SSM) parameter using the following pattern: /tetrascience/production/ECS/ts-service-data-apps/DOMAIN

  For DOMAIN, enter your TDP URL without the https:// (for example, platform.tetrascience.com). A fix for this issue is in development and testing and is scheduled for a future release.

• The Data Lakehouse Architecture doesn't support restricted, customer-hosted environments that connect to the TDP through a proxy and have no connection to the internet. A fix for this issue is in development and testing and is scheduled for a future release.

• On the File Details page, related files links don't work when accessed through the Show all X files within this workflow option. As a workaround, customers should select the Show All Related Files option instead. A fix for this issue is in development and testing and is scheduled for a future release.

• When customers upload a new file on the Search page by using the Upload File button, the page doesn’t automatically update to include the new file in the search results. As a workaround, customers should refresh the Search page in their web browser after selecting the Upload File button. A fix for this issue is in development and testing and is scheduled for a future TDP release.

• Values returned as empty strings when running SQL queries on SQL tables can sometimes return Null values when run on Lakehouse tables. As a workaround, customers taking part in the Data Lakehouse Architecture EAP should update any SQL queries that specifically look for empty strings to instead look for both empty string and Null values.

• The Tetra FlowJo Data App doesn’t load consistently in all customer environments.

• Query DSL queries run on indices in an OpenSearch cluster can return partial search results if the query puts too much compute load on the system. This behavior occurs because the OpenSearch search.default_allow_partial_result setting is configured as true by default. To help avoid this issue, customers should use targeted search indexing best practices to reduce query compute loads. A way to improve visibility into when partial search results are returned is currently in development and testing and scheduled for a future TDP release.

• Text within the context of a RAW file that contains escape (\) or other special characters may not always index completely in OpenSearch. A fix for this issue is in development and testing, and is scheduled for an upcoming release.

• If a data access rule is configured as [label] exists > OR > [same label] does not exist, then no file with the defined label is accessible to the Access Group. A fix for this issue is in development and testing and scheduled for a future TDP release.

• File events aren’t created for temporary (TMP) files, so they’re not searchable. This behavior can also result in an Unknown state for Workflow and Pipeline views on the File Details page.

• When customers search for labels in the TDP UI’s search bar that include either @ symbols or some unicode character combinations, not all results are always returned.

• The File Details page displays a 404 error if a file version doesn't comply with the configured Data Access Rules for the user.

TDP System Administration Known Issues

• Failed files in the Data Lakehouse can’t be reprocessed through the Health Monitoring page. Instead, customers should monitor and reprocess failed Lakehouse files by using the Data Reconciliation, File Processing, or Workflow Processing pages.

• The latest Connector versions incorrectly log the following errors in Amazon CloudWatch Logs:

  • Error loading organization certificates. Initialization will continue, but untrusted SSL connections will fail.
  • Client is not initialized - certificate array will be empty
    These organization certificate errors have no impact and shouldn’t be logged as errors. A fix for this issue is currently in development and testing, and is scheduled for an upcoming release. There is no workaround to prevent Connectors from producing these log messages. To filter out these errors when viewing logs, customers can apply the following CloudWatch Logs Insights query filters when querying log groups. (Issue #2818)
    CloudWatch Logs Insights Query Example for Filtering Organization Certificate Errors

  fields @timestamp, @message, @logStream, @log
  | filter message != 'Error loading organization certificates. Initialization will continue, but untrusted SSL connections will fail.'
  | filter message != 'Client is not initialized - certificate array will be empty'
  | sort @timestamp desc
  | limit 20
  

• If a reconciliation job, bulk edit of labels job, or bulk pipeline processing job is canceled, then the job’s ToDo, Failed, and Completed counts can sometimes display incorrectly.

Upgrade Considerations

During the upgrade, there might be a brief downtime when users won't be able to access the TDP user interface and APIs.

After the upgrade, the TetraScience team verifies that the platform infrastructure is working as expected through a combination of manual and automated tests. If any failures are detected, the issues are immediately addressed, or the release can be rolled back. Customers can also verify that TDP search functionality continues to return expected results, and that their workflows continue to run as expected.

For more information about the release schedule, including the GxP release schedule and timelines, see the Product Release Schedule.

For more details on upgrade timing, customers should contact their CSM.

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Important Data Lakehouse Considerations

Keep in mind the following:

• For customers using proxy servers to access the TDP, Tetraflow pipelines created before customers upgrade to TDP v4.3.1 or higher fail and return a CalledProcessError error. As a workaround, customers should disable any existing Tetraflow pipelines after upgrading to TDP v4.3.1 or higher and then enable them again.
• Customers taking part in the EAP version of the Data Lakehouse will need to reprocess their existing Lakehouse data to use the new GA version of the Lakehouse tables. To backfill historical data into the updated Lakehouse tables, customers should create a Bulk Pipeline Process Job that uses an ids-to-lakehouse pipeline and is scoped in the Date Range field by the appropriate IDSs and historical time ranges.

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Security

TetraScience continually monitors and tests the TDP codebase to identify potential security issues. Various security updates are applied to the following areas on an ongoing basis:

• Operating systems
• Third-party libraries

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Quality Management

TetraScience is committed to creating quality software. Software is developed and tested following the ISO 9001-certified TetraScience Quality Management System. This system ensures the quality and reliability of TetraScience software while maintaining data integrity and confidentiality.

Other Release Notes

To view other TDP release notes, see Tetra Data Platform Release Notes.